Francesca Morreale, PhD
Post-doc
Francesca Morreale, PhD
Post-doc – based at the Research Institute of Molecular Pathology, Vienna, Austria
PhD, University of Messina (Italy )
Post-doc, Division of Biological Chemistry & Drug Discovery, Dundee (UK)
Project
PROTACs are bifunctional small molecules with binding specificities to a known E3 ligase (substrate binding protein) like VHL or Cereblon and a protein of interest (POI).
A PROTAC favours POI binding to a E3 ligase, thereby inducing ubiquitination and proteasomal degradation of the protein.
Goal of the project:
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- Discover new methodologies to generate ternary structural information for weak PROTACS
- Identification and enablement of novel E3 Ligase PROTAC systems beyond VHL or Cereblon
- Develop first in class bacterial PROTAC strategies
Supervisor
Dr. Tim Clausen
Senior Scientist, IMP
PhD, Technical University Munich, Germany
Research interests:
- Molecular mechanisms of protein quality control
- Protein degradation in bacterial and mammalian systems
Supervisor
Dr. Dirk Kessler
Scientific Director Structural Research
PhD Structural Biology, University of Freiburg, Germany
Research interests:
- Protein Crystallography
- Undrugged targets in Oncology
- New technologies in SR/Biophysics