Dr. Olga Petrova
Post-doc
Dr. Olga Petrova
Post-doc – based at the Research Institute of Molecular Pathology
PhD in Biochemistry/Molecular Biology, 2018, Lomonosov Moscow State University, Russia
Project
PROTACs are bifunctional small molecules that can selectively degrade target proteins. PROTAC links a protein of interest (POI) with E3 ubiquitin ligase what leads to protein ubiquitination and degradation by proteasome. This approach has a huge potential to cure different diseases, for example, targeting tumor-addicted oncoproteins is a promising strategy in cancer therapies.
Goal of the project: Identification and structural characterization of novel E3 Ligase PROTAC systems
Supervisor
Dr. Tim Clausen
Senior Group Leader, Research Institute of Molecular Pathology, Vienna, Austria
PhD, Technical University Munich, Germany
Research interests:
- Molecular mechanisms of protein quality control
- Protein degradation in bacterial and mammalian systems
Supervisor
Dr. Dirk Kessler
Scientific Director Structural Research
PhD Structural Biology, University of Freiburg, Germany
Research interests:
- Protein Crystallography
- Undrugged targets in Oncology
- New technologies in SR/Biophysics