Dr. Markus Schäfer
Post-doc
Dr. Markus Schäfer
Post-doc – based at the Research Institute of Molecular Pathology, Vienna, Austria
PhD in Molecular Biology, Research Institute of Molecular Pathology, Vienna, Austria
Project
Cytotoxic CD8 T cells are often functionally suppressed by the tumor microenvironment. Therapies aimed at re-establishing or enhancing CD8 T cell function in human tumors have led to major clinical breakthroughs. Though, the success of such immunotherapies remains limited to certain cancer types and T cell intrinsic mechanisms mediating suppression remain incompletely understood. Our aim is to genetically study T cell suppression pathways and search for additional (potentially small-molecule) immunomodulatory targets by multiplexed CRISPR/Cas9-based screening methodology in CD8 T cells.
Supervisor
Dr. Johannes Zuber
Research Group Leader, IMP - Research Institute of Molecular Pathology, Vienna, Austria
MD, Humboldt-University of Berlin, Germany
Research interests:
- Searching for exploitable genetic interactions in AML and PDAC
- Exploring and exploiting aberrant self-renewal in leukemia
- Finding and probing immunomodulatory targets in tumor-associated T-cells
Supervisor
Dr. Sebastian Carotta
Director, Cancer Cell Signaling Department, BI RCV, Vienna, Austria
PhD, IMP – Research Institute of Molecular Pathology , Vienna, Austria
Research interests:
- Cancer Immunotherapy
- Immunogenic Cell Death
- Innate Immunity
- Genetic and phenotypic screening in tumor and immune cells