Dr. Julia Leodolter
Post-doc
Dr. Julia Leodolter
Post-doc – based at the Research Institute of Molecular Pathology, Vienna, Austria
PhD, Institute of Molecular Biology and Biophysics, ETH Zurich (Switzerland)
Project
PROTACs are bifunctional small molecules that target a protein of interest (POI) to an E3 ligase, thereby inducing ubiquitination and subsequent proteasomal degradation of the protein. This approach shows promises in eukaryotes e.g. as cancer treatment.
GOAL: a joint project has been initiated with Research Beyond Borders to bring the PROTAC approach to the bacterial world (bacPROTAC). We aim to develop bifunctional bacPROTAC molecules that target essential POIs for degradation by bacterial proteolytic complexes. This approach could potentially be used as treatment modality against drug-resistant strains of the pathogen Mycobacterium tuberculosis.
Supervisor
Dr. Tim Klausen
Senior Group Leader, Research Institute of Molecular Pathology, Vienna, Austria
Research interests:
- Molecular mechanisms of protein quality
- Protein degradation in bacterial and mammalian systems
Supervisor
Dr. Guido Boehmelt
Director External Innovation, Research Beyond Borders
PhD, University of Vienna (Austria)
Research interests:
- Novel therapeutic modalities and concepts
- Global external research partnerships
- Fostering Austrian life science ecosystem interaction with BI