Dr. Jonas Weinmann
Post-doc
Dr. Jonas Weinmann
Post-doc – Drug Discovery Sciences
PhD in Virology, University of Heidelberg (Germany)
Project
Establishment of a robust system for the modulation of target gene expression. To this end, adeno-associated viruses (AAVs) will be used as a tool for the delivery of CRISPR/Cas or RNAi which will be compared head-to-head in vivo. Parameters such as construct size, applicability and most importantly gene knock-out/knock-down efficiency will be assessed. Ultimately, one functional and robust system to alter gene expression should emerge that can be applied for upcoming target validations.
Supervisor
Dr. Thorsten Lamla
Principal Scientist, Laboratory Head in Drug Discovery Sciences
PhD in Biochemistry, Freie Universität Berlin (Germany)
Research interests:
- Production, purification and QC of viral vectors (AAV and LV) for preclinical research
- Target validation by AAV-mediated overexpression or knock-down of a target gene in rodent animal models
- Transduction (transient and stable) of cell lines, primary cells and organoids