Development Publications

  • Validation Is Not Verification: Precise Terminology and Scientific Methods in Bioprocess Modeling.

    Smiatek J; Jung A; Bluhmki E. Trends in Biotechnology 2021; .

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  • Carbamoyl Anion Addition to Azirines.

    Kerner M.J.; Kuttruff C.A.; Chevliakov M; et al. Organic letters 2021; 23 (11) : 4396-4399.

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  • Challenges in tackling energy expenditure as obesity therapy - from preclinical models to clinical application. [Review]

    Loffler MC; Betz MJ; Blondin DP; et al. Molecular Metabolism 2021; : 101237.

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  • Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice.

    Hansen H.H.; Gronlund R.V.; Baader-Pagler T.; et al. Scientific reports 2021; 11 (1) : 8060.

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  • A Noncoordinating Acid-Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols.

    Fandrick, Keith R; Patel ND; Radomkit S; et al. The Journal of organic chemistry 2021; 86 (6) : 4877-4882.

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  • Application of Metabolic Modeling for Targeted Optimization of High Seeding Density Processes.

    Brunner M; Kolb K; Keitel A; et al. Biotechnology and bioengineering 2021; 118 (5) : 1793-1804.

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  • Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography.

    Saleh D; Hess R; Ahlers-Hesse M; et al. Biotechnology and bioengineering 2021; .

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  • Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation-relevant mechanisms.

    Klingler F.; Mathias S.; Schneider H.; et al. Biotechnology and bioengineering 2021; .

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  • "High-risk" host cell proteins (HCPs): A multi-company collaborative view.

    Jones M.; Palackal N.; Wang F; et al. Biotechnology and bioengineering 2021; .

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  • A linear scale-up approach to fluid bed granulation.

    Emenike VN; Kulla I; Maus M; et al. International journal of pharmaceutics 2021; : 120209.

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  • HP-beta-CD for the formulation of IgG and Ig-based biotherapeutics.

    Wu H.H.; Garidel, Patrick; Michaela B.. International journal of pharmaceutics 2021; 601 : 120531.

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  • Investigating Photodegradation of Antibodies Governed by the Light Dosage.

    Kaiser W; Schultz-Fademrecht T; Blech M; et al. International journal of pharmaceutics 2021; 604 : 120723.

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  • Oil-Immersion Flow Imaging Microscopy for Quantification and Morphological Characterization of Submicron Particles in Biopharmaceuticals.

    Krause N.; Kuhn S.; Frotscher E.; et al. AAPS Journal 2021; 23 (1) .

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  • Ocular and systemic pharmacokinetics of BI-X, a nanobody targeting VEGF and Ang-2, after intravitreal dosing in cynomolgus monkeys - Evidence for half-life extension by albumin.

    Fuchs, Holger; Chen, Lin-Zhi; Low S; et al. Experimental Eye Research 2021; 205 .

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  • Discovery of a Series of Pyrazinone RORgamma Antagonists and Identification of the Clinical Candidate BI 730357.

    Harcken, Christian; Csengery J; Turner M; et al. ACS Medicinal Chemistry Letters 2021; 12 (1) : 143-154.

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  • Exosomal mirnas as potential biomarkers to monitor phosphodiesterase 5 inhibitor induced anti-fibrotic effects on CCl4 treated rats.

    Broermann, Andre; Schmid, Ramona; Gabrielyan O.; et al. International Journal of Molecular Sciences 2021; 22 (1) : 1-22.

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  • Extensive histopathological characterization of inflamed bowel in the dextran sulfate sodium mouse model with em-phasis on clinically relevant biomarkers and targets for drug development.

    Bonfiglio R.; Galli F.; Varani M.; et al. International Journal of Molecular Sciences 2021; 22 (4) : 1-20.

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  • Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.

    Ebenhoch R; Bauer M; Reinert, Dirk; et al. JOURNAL OF STRUCTURAL BIOLOGY 2021; 213 (1) .

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  • Hydrolytic polysorbate 20 degradation - Sensitive detection of free fatty acids in biopharmaceuticals via UPLC-QDa analytics with isolator column.

    Evers D.-H.; Carle S.; Lakatos D.; et al. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2021; 1174 .

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  • An Industry Perspective on the Challenges of Using Closed System Transfer Devices with Biologics and Communication Guidance to Healthcare Professionals.

    Gopalrathnam G; Christian T; Jagannathan B; et al. Journal of pharmaceutical sciences 2021; 110 (6) : 2329-2335.

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