Publications

RESEARCH

  • Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population (Nature, (2023), 613, 7944, (508-518), 10.1038/s41586-022-05473-8)

    Kurki M.I.; Karjalainen J.; Palta P.; et al Nature 2023; 615 (7952) : E19

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  • FinnGen provides genetic insights from a well-phenotyped isolated population

    Kurki M.I.; Karjalainen J.; Palta P.; et al Nature 2023; 613 (7944) : 508-518

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  • Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature

    Ralser A; Dietl A; Jarosch S; et al Gut 2023; 72 (7) : 1258-1270

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  • Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome

    Tsetsos F.; Topaloudi A.; Jain P.; et al Biological psychiatry 2023;

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  • Microarray patches for managing infections at a global scale. [Review]

    Anjani QK; Sabri AHB; Hutton AJ; et al Journal of Controlled Release 2023; 359 : 97-115

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  • Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

    Schloesser D.; Lindenthal L.; Sauer J.; et al The Journal of cell biology 2023; 222 (2)

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  • Cardioprotective Effect of Empagliflozin and Circulating Ketone Bodies During Acute Myocardial Infarction

    Santos-Gallego C.G.; Requena-Ibanez J.A.; Picatoste B.; et al Circulation. Cardiovascular imaging 2023; 16 (4) : e015298

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  • Visual Functions of the Primate Superior Colliculus

    Hafed Z.M.; Hoffmann K.-P.; Chen C.-Y.; et al Annual review of vision science 2023; 9 : 361-383

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  • The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

    Vergara A.; Llorens-Cebria C.; Martos N.; et al Clinical Science 2023; 137 (1) : 87-104

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  • Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of Paracoccidioides brasiliensis as a benchmark study

    Ochoa R.; Cardim-Pires T.R.; Sant'Anna R.; et al Computational and Structural Biotechnology Journal 2023; 21 : 1746-1758

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  • The Pre-Stroke Induction and Normalization of Insulin Resistance Respectively Worsens and Improves Functional Recovery

    Vercalsteren E; Karampatsi D; Dekens D; et al International Journal of Molecular Sciences 2023; 24 (4)

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  • The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology

    Di Bartolomeo M; Stark T; Di Martino S; et al International Journal of Molecular Sciences 2023; 24 (4)

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  • Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia. [Review]

    Rosenbrock, Holger; Desch M; Wunderlich G European Archives of Psychiatry and Clinical Neuroscience 2023; 273 (7) : 1557-1566

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  • How can we discover developable antibody-based biotherapeutics?. [Review]

    Bauer J; Rajagopal N; Gupta P; et al Frontiers in Molecular Biosciences 2023; 10 : 1221626

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  • Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans

    Tammen H.; Komhoff M.; Delic D; et al Scientific reports 2023; 13 (1) : 601

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  • BIreactive: Expanding the Scope of Reactivity Predictions to Propynamides

    Hermann M.R.; Tautermann CS; Sieger P; et al Pharmaceuticals 2023; 16 (1)

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  • Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

    Jain P; Miller-Fleming T; Topaloudi A; et al Translational Psychiatry 2023; 13 (1) : 69

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  • Triple-tyrosine kinase inhibition by BIBF1000 attenuates airway and pulmonary arterial remodeling following chronic allergen challenges in mice

    Gurusamy M.; Nasseri S; Rampa D.R.; et al European Journal of Medical Research 2023; 28 (1)

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  • Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species

    Cordes H.; Rapp H. CPT: pharmacometrics & systems pharmacology 2023; 12 (3) : 311-319

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  • TRPV1 modulation of contextual fear memory depends on stimulus intensity and endocannabinoid signalling in the dorsal hippocampus

    Iglesias L.P.; Fernandes H.B.; de Miranda A.S.; et al Neuropharmacology 2023; 224

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  • Investigating neuropsychological and reward-related deficits in a chronic corticosterone-induced model of depression

    Hales C.A.; Stuart S.A.; Griffiths J.; et al Psychoneuroendocrinology 2023; 147

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  • Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure

    Tsioti I.; Steiner B.L.; Escher P.; et al Journal of Neuroinflammation 2023; 20 (1)

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  • Local immunotherapy with the RNA-based immune stimulator CV8102 induces substantial anti-tumor responses and enhances checkpoint inhibitor activity

    Lutz J; Meister M; Habbeddine M; et al Cancer Immunology, Immunotherapy 2023; 72 (5) : 1075-1087

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  • Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice

    Tyree S.M.; Jennings K.J.; Gonzalez O.C.; et al Communications Biology 2023; 6 (1) : 74

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  • The SGLT2 inhibitor empagliflozin improves cardiac energy status via mitochondrial ATP production in diabetic mice

    Choi J.; Matoba N.; Setoyama D.; et al Communications Biology 2023; 6 (1) : 278

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  • Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice

    Madur L.; Ineichen C.; Bergamini G.; et al Communications Biology 2023; 6 (1) : 422

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  • Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophrenia

    Brum M.; Nieberler M.; Kehrwald C.; et al World Journal of Biological Psychiatry 2023; 24 (7) : 564-577

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  • Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study

    Michal M.; Schulz A.; Wild P.S.; et al BMC Psychiatry 2023; 23 (1)

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  • Transcriptomic and proteomic profiling of young and old mice in the bleomycin model reveals high similarity

    Klee S.; Picart-Armada S.; Wenger K.; et al American Journal of Physiology - Lung Cellular & Molecular Physiology 2023; 324 (3) : L245-L258

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  • Antifibrotic Drug Nintedanib Inhibits CSF1R to Promote IL-4-associated Tissue Repair Macrophages

    Watson C.K.; Schloesser D.; Fundel-Clemens K; et al American journal of respiratory cell and molecular biology 2023; 68 (4) : 366-380

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  • Whole lung proteome of an acute epithelial injury mouse model in comparison to spatially resolved proteomes

    Griesser E.; Gesell M.; Veyel D; et al Proteomics 2023; 23 (10)

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  • The polymorph landscape of Dabigatran etexilate mesylate: Taking the challenge to bring a metastable polymorph to market

    Sieger P; Werthmann U; Saouane S. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023; 186 : 106447

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  • Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition

    Hofmann I; Baum, Anke; Hofmann MH; et al The Journal of pharmacology and experimental therapeutics 2023; 384 (3) : 331-342

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  • MELLODDY: Cross-pharma Federated Learning at Unprecedented Scale Unlocks Benefits in QSAR without Compromising Proprietary Information

    Heyndrickx W; Mervin L; Morawietz T; et al Journal of chemical information and modeling 2023;

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  • Target 2035 - an update on private sector contributions

    Ackloo S.; Antolin A.A.; Bartolome J.M.; et al RSC Medicinal Chemistry 2023; 14 (6) : 1002-1011

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  • Functional ultrasound detects frequency-specific acute and delayed S-ketamine effects in the healthy mouse brain

    Ionescu TM; Grohs-Metz G; Hengerer B Frontiers in Neuroscience 2023; 17 : 1177428

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  • Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system

    Chen X; Delic D; Cao Y.; et al American journal of physiology. Cell physiology 2023; 324 (4) : C951-C962

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  • Deciphering integration loci of CHO manufacturing cell lines using long read nanopore sequencing

    Clappier C.; Bottner D.; Heinzelmann D.; et al New biotechnology 2023; 75 : 31-39

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  • Analyzing proteolytic stability and metabolic hotspots of therapeutic peptides in two rodent pulmonary fluids

    Wesche F.; De Maria L.; Leek T.; et al Journal of pharmaceutical and biomedical analysis 2023; 224

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  • Kinase Degraders, Activators, and Inhibitors: Highlights and Synthesis Routes to the Chemical Probes on opnMe.com, Part 1

    Gollner A; Heine C; Hofbauer KS ChemMedChem 2023; 18 (10) : e202300031

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  • Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus maze

    Hilton J.R.; Simpson S.R.; Sherman E.R.; et al European Journal of Neuroscience 2023; 57 (1) : 54-63

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  • Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice

    Winter M; Simon R.P.; Habe T.T.; et al SLAS Discovery 2023; 28 (5) : 240-246

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  • Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay

    Bitzer S; Harati MD; El Kasmi KC; et al SLAS Discovery 2023; 28 (4) : 149-162

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DEVELOPMENT

  • The evolving role of investigative toxicology in the pharmaceutical industry

    Pognan F.; Beilmann M; Boonen H.C.M.; et al Nature reviews. Drug discovery 2023; 22 (4) : 317-335

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  • N1-Methylnicotinamide as Biomarker for MATE-Mediated Renal Drug-Drug Interactions: Impact of Cimetidine, Rifampin, Verapamil, and Probenecid

    Muller F; Hohl K; Keller S.; et al Clinical pharmacology and therapeutics 2023; 113 (5) : 1070-1079

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  • Development of Pharmacophore Models for the Important Off-Target 5-HT2B Receptor

    Schieferdecker S.; Vock E Journal of medicinal chemistry 2023; 66 (2) : 1509-1521

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  • How can we discover developable antibody-based biotherapeutics?. [Review]

    Bauer J; Rajagopal N; Gupta P; et al Frontiers in Molecular Biosciences 2023; 10 : 1221626

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  • Protein-protein interactions in solutions of monoclonal antibodies probed by the dependence of the high-frequency viscosity on temperature and concentration

    Rott E; Leppin C; Diederichs T; et al Analyst 2023; 148 (8) : 1887-1897

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  • Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview. [Review]

    Stroppel L; Schultz-Fademrecht T; Cebulla M; et al Pharmaceutics 2023; 15 (2)

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  • Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

    Gierke H; Mouchantat S; Berg S; et al Pharmaceutics 2023; 15 (3)

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  • Incorporating random effects in biopharmaceutical control strategies

    Oberleitner T.; Zahel T.; Kunzelmann M.; et al AAPS Open 2023; 9 (1)

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  • Influence of PLGA End Groups on the Release Profile of Dexamethasone from Ocular Implants

    Saraf I.; Kushwah V.; Alva C.; et al Molecular pharmaceutics 2023; 20 (2) : 1307-1322

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  • Existence of a superior polysorbate fraction in respect to protein stabilization and particle formation?

    Diederichs T.; Mittag J.J.; Humphrey J.; et al International journal of pharmaceutics 2023; 635

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  • Protein photodegradation in the visible range? Insights into protein photooxidation with respect to protein concentration

    Hipper E.; Lehmann F.; Kaiser W.; et al International journal of pharmaceutics 2023; 5

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  • Oxidation of polysorbates - An underestimated degradation pathway?. [Review]

    Weber J; Buske J; Mader K; et al International journal of pharmaceutics 2023; 6 (X) : 100202

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  • Micro-Flow Imaging multi-instrument evaluation for sub-visible particle detection

    Fawaz I.; Schaz S.; Boehrer A.; et al European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2023; 185 : 55-70

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  • Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation

    Hess R.; Yun D.; Saleh D.; et al Journal of chromatography. A 2023; 1690

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  • Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition

    Hofmann I; Baum, Anke; Hofmann MH; et al The Journal of pharmacology and experimental therapeutics 2023; 384 (3) : 331-342

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  • An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies, instruments, and epsilon-aminocaproic acid lots

    Wiesner R.; Zagst H.; Lan W.; et al Electrophoresis 2023;

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  • Deciphering integration loci of CHO manufacturing cell lines using long read nanopore sequencing

    Clappier C.; Bottner D.; Heinzelmann D.; et al New biotechnology 2023; 75 : 31-39

    Read abstract

TRANSLATIONAL MEDICINE

  • Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

    Allesoe R.L.; Lundgaard A.T.; Hernandez Medina R.; et al Nature biotechnology 2023; 41 (3) : 399-408

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  • An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles

    Barreiro K.; Lay A.C.; Leparc G; et al Journal of Extracellular Vesicles 2023; 12 (2) : e12304

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  • Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain

    Gartner M.; Weigand A.; Keicher C.; et al Neuropsychobiology 2023; 82 (2) : 91-103

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  • Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

    Liu S.; Zhao Y; Lu S; et al Genome Medicine 2023; 15 (1)

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  • N1-Methylnicotinamide as Biomarker for MATE-Mediated Renal Drug-Drug Interactions: Impact of Cimetidine, Rifampin, Verapamil, and Probenecid

    Muller F; Hohl K; Keller S.; et al Clinical pharmacology and therapeutics 2023; 113 (5) : 1070-1079

    Read abstract
  • 4B-OH CHOLESTEROL AS ENDOGENOUS BIOMARKER FOR CYP3A4 INDUCER DDI STUDIES -A PBPK PLATFORM FOR IN SILICO COMPOUND TESTING

    Balazki P.; Martins F.; Montaseri G.; et al Clinical pharmacology and therapeutics 2023; 113 (Supplement+1) : S44-S45

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  • Significant impact of time-of-day variation on metformin pharmacokinetics

    Turk D.; Scherer N.; Selzer D.; et al Diabetologia 2023; 66 (6) : 1024-1034

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  • 89Zr-immuno-PET using the anti-LAG-3 tracer [89Zr]Zr-BI 754111: demonstrating target specific binding in NSCLC and HNSCC

    Miedema I.H.C.; Huisman M.C.; Zwezerijnen G.J.C.; et al European journal of nuclear medicine and molecular imaging 2023; 50 (7) : 2068-2080

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  • Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia. [Review]

    Rosenbrock, Holger; Desch M; Wunderlich G European Archives of Psychiatry and Clinical Neuroscience 2023; 273 (7) : 1557-1566

    Read abstract
  • Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans

    Tammen H.; Komhoff M.; Delic D; et al Scientific reports 2023; 13 (1) : 601

    Read abstract
  • Updated data from the phase I Beamion Lung 1 trial of BI 1810631, a HER2 TKI, in patients (pts) with advanced solid tumours with HER2 aberrations

    Opdam F.; Heymach J.; Barve M.; et al Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2023; 18 (4+Supplement) : S63-S64

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  • Cell-level systems biology model to study inflammatory bowel diseases and their treatment options

    Stubler S.; Kloft C.; Huisinga W. CPT: pharmacometrics & systems pharmacology 2023;

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  • Pharmacometrics enhanced Bayesian borrowing approach to improve clinical trial efficiency: Case of empagliflozin in type 2 diabetes

    Fayette L; Sailer MO; Perez-Pitarch A CPT: pharmacometrics & systems pharmacology 2023;

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  • Radioimmune Imaging of alpha4beta7 Integrin and TNFalpha for Diagnostic and Therapeutic Applications in Inflammatory Bowel Disease

    Signore A; Bonfiglio R; Varani M; et al Pharmaceutics 2023; 15 (3)

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  • Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study

    Michal M.; Schulz A.; Wild P.S.; et al BMC Psychiatry 2023; 23 (1)

    Read abstract
  • Antifibrotic Drug Nintedanib Inhibits CSF1R to Promote IL-4-associated Tissue Repair Macrophages

    Watson C.K.; Schloesser D.; Fundel-Clemens K; et al American journal of respiratory cell and molecular biology 2023; 68 (4) : 366-380

    Read abstract
  • Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition

    Hofmann I; Baum, Anke; Hofmann MH; et al The Journal of pharmacology and experimental therapeutics 2023; 384 (3) : 331-342

    Read abstract
  • Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system

    Chen X; Delic D; Cao Y.; et al American journal of physiology. Cell physiology 2023; 324 (4) : C951-C962

    Read abstract
  • Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates: Findings From In Vitro Analyses and an Open-Label, Single-Sequence Phase I Study

    Desch M; Schlecker C; Hohl K; et al Journal of clinical psychopharmacology 2023; 43 (2) : 113-121

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  • Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay

    Bitzer S; Harati MD; El Kasmi KC; et al SLAS Discovery 2023; 28 (4) : 149-162

    Read abstract

BIOPHARMACEUTICALS